New selective PAD4 inhibitors binding a calcium-deficient form of the PAD4 enzyme have validated the significant enzymatic role of human and mouse PAD4 in both histone citrullination and neutrophil extracellular lure development for, to our know-how, The very first time. The therapeutic opportunity of PAD4 inhibitors can now be explored. https://edwardo877alw9.izrablog.com/profile