There exists a release of norepinephrine in the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors while in the dorsal horn to minimize afferent suffering transmission and produce analgesia. Hence, medications like clonidine that focus on alpha-2 receptors can impact the transmission of agony. : linked to, served by, https://www.proleviate.com/post/the-new-pain-killer-conolidine