There's a release of norepinephrine with the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors in the dorsal horn to lessen afferent discomfort transmission and deliver analgesia. Thus, drugs like clonidine that concentrate on alpha-two receptors can impact the transmission of discomfort. Combining these coronary heart medicines with clonidine https://peterw554cyr3.national-wiki.com/user