Chemotherapy was potentiated by E7449 and one agent experienced significant antitumor action in BRCA-deficient xenografts. On top of that, E7449 inhibited Wnt/β-catenin signaling in colon most cancers mobile lines, most likely by way of TNKS inhibition. In step with this possibility, E7449 stabilized axin and TNKS proteins causing β-catenin de-stabilization https://mahendrav752mrw6.dekaronwiki.com/user