DNA ligases seal 5′-PO4 and three′-OH polynucleotide finishes by using a few nucleotidyl transfer ways involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are critical guardians of genomic integrity, and ligase dysfunction underlies human genetic disorder syndromes. Crystal constructions of DNA ligases bound to nucleotide and nucleic acid substrates have https://carsonl890vpk5.wikicorrespondent.com/user