Cobicistat will increase the amount or influence of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. chloramphenicol will raise the level or influence of bortezomib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Keep an eye on Intently (one)mitotane decreases levels of bortezomib by affecting hepatic/intestinal enz... https://henrikg554ufp7.onzeblog.com/profile